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Overview Edit

The Pathogen Portal database is a collection, which focuses on the three parts of the disease triangle, and is linked to five Bioinformatic Resource Centers (BRCs). Each of the five BRCs focus on a different class of pathogens. Host-Vector-Environment interactions are integrated by the Pathogen Portal database to better understand the bioinformatics of infectious diseases. These interactions are of special interest to those who work in the healthcare industry. Each of the five BRCs focus on a different class of pathogens.

History and Uses Edit

The Pathogen Portal database was initiated in 2004 to serve as a collection of pathogen bioinformatics. It has expanded to include five Bioinformatic Recourse Centers (BRCs), each of which specializes in a different catagory of infectious diseases. These include all bacterial species of pathogens, all viral families of pathogens, all eukaryotic pathogen species, invertebrate vectors of human pathogens, and the influenza virus. These centers also include data for pathogens listed as priortiy A-C for biodefence research by the National Instiute of Allergy and Infectious Diseases (NIAID). Each of the five BRCs:

  1. Store and update bioinformatic information related to the genome sequence, research data types, functional genomics, proteomics, metagenomics, and other -omics.
  2. Store data related to the epidemiology, surveillance, population genetics, genotype/phenotype association, antimicrobial resistance, expression data, antigenic data, and other basic research and clinical data as well as metadata.
    Screen Shot 2014-09-07 at 7.50.43 PM

    Pathogen Portal Homepage

  3. Utilize and make available bioinformatic tools and analytical resources and services to analyze the data.
  4. The five centers offer bioinformatics training on site.
  5. Establish "Driving Biological Projects" to bring bioinformatics to research laboratories around the globe.

Bioinformatic information is also avaliable on many emerging/re-emerging infectious diseases. All the data and tools offered through the Pathogen Portal database are avaliable to the public.

Example Edit

Screen Shot 2014-09-07 at 7.56.29 PM

To view the bioinformatic information for a specific pathogen:

  1. Click the pathogen button on the Pathogen Portal homepage.
  2. Then click either the genome or protein-protein interactions you are interested in researching.
  3. For protein interactions select both a vecotr (i.e. Homo) and a pathogen (i.e. Chlamydiia) to research their specific interactions.
  4. Then click view interactions to see the protein interactions between the host and the pathogen of your choice.

For example, the protein interactions between Chlamydiia trachomatis and Homo sapiens happen when the pathogenic DO serine protease interacts with the hosts Beta-casein.

References Edit

Pathogen Portal. (2014, April 7). Retrieved September 8, 2014.

List of biological databases. (2014, August 28). Retrieved September 8, 2014.

-Images included from screenshots taken of Pathogen Portal webpage on September 8, 2014.